Search results for "Successful completion"
showing 3 items of 3 documents
Mouse models of multiple myeloma: technologic platforms and perspectives.
2018
Murine models of human multiple myeloma (MM) are key tools for the study of disease biology as well as for investigation and selection of novel candidate therapeutics for clinical translation. In the last years, a variety of pre-clinical models have been generated to recapitulate a wide spectrum of biological features of MM. These systems range from spontaneous or transgenic models of murine MM, to subcutaneous or orthothopic xenografts of human MM cell lines in immune compromised animals, to platform allowing the engraftment of primary/bone marrow-dependent MM cells within a human bone marrow milieu to fully recapitulate human disease. Selecting the right model for specific pre-clinical re…
Subfascial Endoscopic Perforator Surgery With Tumescent Local Anesthesia
2002
background. Subfascial endoscopic perforator surgery (SEPS) has become an established procedure. objective. To evaluate SEPS with tumescent local anesthesia (TLA) using an single-port device originally designed for that purpose. methods. Patients selected for SEPS received subcutaneous infiltration of TLA into the medial aspect of the calf 20 minutes before surgery. Bipolar coagulation and dissection were used to treat incompetent perforators. results. Fifty-one patients with 67 legs of CEAP stages C3–C6 underwent SEPS with TLA. In 40 patients or 53 legs (79.1%) TLA alone allowed successful completion of the SEPS procedure. Five patients with 7 legs (10.4%) required additional intravenous a…
Introduction : From Fundamentals to Advances in Crowdfunding Research and Practice
2020
AbstractThe chapter introduces the phenomenon of crowdfunding while presenting its definition and main manifestations in recent years. It then discusses the roles played by the various parties to a crowdfunding transaction, as well as the benefits each may gain from such engagement. Overall, it argues for a win-win situation, where all parties become better off from involvement in a responsible crowdfunding engagement. Furthermore, the chapter highlights the process dimension of crowdfunding, as represented through a series of three main stages, which are further specified into a seven sub-stage model. Each stage in the process depends on successful completion of the stage preceding it and …